TriphenylphosphoniuM BroMide HydrobroMide Making For OLOPATADINE HCL 27710-82-3

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 27710-82-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA

Supply Ability: 100KG

Certificate: ISO

Product Description

Olopatadine Hydrochloride Triphenylphosphonium bromide hydrobromide CAS number is 27710-82-3, full name is [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide, which is mainly used for the preparation of olopatadine free base by the wittig reaction with Isoxepac. After salt formation, get the final product Olopatadine Hydrochloride, the process is as follows:process olopatadine hydrochloride triphenylphosphonium bromide hydrobromide and sodium hydride reaction for 3 ~ 4h, generating wittig reagent 3- (dimethylaminopropyl triphenyl) phosphorus ylide, Add isoxepac,take reaction, extracted with ethyl acetate to remove impurity, use n-butanol extract the product, concentrated, beating, obtain olopatadine free base mixture. Among them, the reaction time of Isoxepac was the best for 24h. Finally, the olopatadine free base mixture is dissolved in acetone, dropwise hydrochloric acid, stirred, filtered, the filter cake is washed with acetone and dried to obtain the final product olopatadine hydrochloride.The appearance of Olopatadine Hydrochloride Triphenylphosphonium bromide hydrobromide CAS number 27710-82-3 is looks white crystalline powder ,with a single impurity less than 0.5% and purity more than 99%. The inventory is usually kept above tonnage.

Thera. Category:allergic conjunctivitis

Cas No.:27710-82-3  

Synonym:triphenylphosphoniuM broMide hydrobroMide;(3-(DiMethylaMino)propyl)triphenylphosphoniuM broMide hydrobroMide puruM;(3-diMethylaMinopropyl)triphenylphospho-niuM broMo hydrobroMide;(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDROBROMIDE 98%;(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HBR;(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDROBROMIDE;[3-(Dimethylamino)pr;[3-(DiMethylaMino)propyl]triphenylphosphoniuM broM;


Molecular Weight: 509.26

Molecular formula:C23H28Br2NP

Purity: ≥99.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage:It can treat eye itching caused by pink eye

Related intermediate:

Chemical name Specification Color
Isoxepac HPLC 99.0%  offer white powder
Melt point 137~142
Loss on drying 0.5%



HPLC 99.0% white crystalline powder
Single impurity 0.5%
Loss on drying 0.5% 
Assay 98.5%
OLOPATADINE HCL HPLC 99.75%  white crystalline powder
Single impurity 0.1%
PH 2.0~4.0
Loss on drying 0.3% 
Residue on ignition

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