Methyl 2-(Bromomethyl)-3-Nitrobenzoate For Lenalidomide 98475-07-1

Basic Info

Model No.: 98475-07-1

Additional Info

Packaging: As required

Productivity: Commercial

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

Lenalidomide bromide CAS 98475-07-1. There have been a lot of reports on his preparation methods, the most typical of which are two methods as following:
The first one, 2-methyl-3-nitro-benzoic acid as a raw material, through methyl esterification and bromination reaction to obtain 2-bromomethyl 3-nitro-benzoic acid methyl ester, the method reported time is early, in which the methyl 2-bromomethyl 3-nitro-benzoate was subjected to radical reaction with NBS by ultraviolet light irradiation, and the solvent was refluxed for a long time with carbon tetrachloride or chloroform as a solvent. Obtained by bromination. The reaction conditions are harsh, it is difficult to produce amplification, and a large amount of toxic solvent is used, which is difficult for the labor protection of production workers, and has been rarely used.
The second one, uses 2-methyl-3-nitro-benzoic acid methyl ester as raw material, N-bromosuccinimide (NBS) as brominating reagent, and azobisisobutyronitrile (AIBN) as the initiator, which is harsh in conditions, it is not conducive to industrial production and environmental protection.

Thera. Category:  Anti-tumor

Cas No.:98475-07-1

Synonyms: 2-BroMoMethyl-3-nitrobenzoate Methyl ester;2-Bromomethyl-3-NitrobenzoicAcidMethylEster;Benzoic acid, 2-(broMoMethyl)-3-nitro-, Methyl ester;Methyl 2-bromomethyl;Lenalidomide Impurity 5;2-Bromomethyl-3-nitro-benzoic acid;Methyl 2-bromomethyl-3-nitrobenzoate;Methyl 2- bromomethyl-3-nitrobezoate;

NW:274.068 

M.W.:C9H8BrNO4

Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request