Nintedanib Intermediate 4,Cas 1174335-83-1

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 1174335-83-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Nintedanib intermediate 4 CAS number is 1174335-83-1, the general operation is taking reaction of 2-Oxindole-6-carboxylic acid methyl ester and acid chlorination reagent chloroacetic anhydride to get chloride compound, then the compound and the original three Methyl ester to take condensation to obtain the target compound nintedanib intermediate 4. His specific synthetic experiment process is as follows: 1. In a 3000mL four-necked round-bottomed flask, equipped with mechanical stirring, reflux condenser, thermometer, a round bottom flask was added 1500mL toluene with protection of nitrogen, 240g 6- methoxycarbonyl -2 - oxoindoline, 272g chloroacetic anhydride, open stirring, warmed to 80 ~ 90 ℃, keep warm and stirred for 6 hours, turn off the heating, naturally reduced to 80 ℃, 600ml of cyclohexane was added, stirring was continued to cool down to room temperature , A solid precipitated, suction filtered, the filter cake was washed with ice-ethanol ,vacuum dried to give 233.6g.
2. In a 5000 mL three-necked flask, 195 g of the solid obtained in the first step, 1.8 L of toluene and 257 g of acetic anhydride were added.and heated to reflux. Then, 267 g of trimethyl benzoate was added and refluxed for 4 hours. Heating was stopped and cooled to room temperature , A large number of solid precipitation, the reaction system was added 100ml n-hexane, low temperature crystallization,Suction filtration, dried under vacuum to give a 100gram pale yellow solid, the light yellow solid is the target compound Nintedanib intermediate 4 CAS number 1174335-83-1

Thera. Category:  Anti-cancer

Cas No.:  1174335-83-1



Molecular Weight:  

Molecular formula:C20H16ClNO5

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html