Nintedanib Intermediate 3 CAS Number 1160293-25-3

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 1160293-25-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Nintedanib intermediate 3 CAS number is 1160293-25-3, with chemical name of 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, his synthetic route is as follows: 1. 4-chloro-3-nitrobenzoic acid was suspended in methanol, after adding thionyl chloride ,take  heating and refluxing reaction, and then cooled , Centrifuged and dried to give the first step methyl 4-chloro-3-nitrobenzoate. 2. Sodium tert-pentoxide was added to the Dimethyl malonate, which was then added to a hot solution of N-methyl-2- Pyrrolidone ; and then stirred and cooled, the mixture was acidified with dilute hydrochloric acid to pH = 1, filtered to obtain a solid, the solid was dissolved in acetic acid, added palladium on carbon catalyst catalytic hydrogenation at 45 ℃;after hydrogenation stopped , Heating the reaction material, filtering off the catalyst after heating, adding water at about 50 ° C, cooling the product to 5 ° C, centrifuging and drying at 50 ° C to obtain the second product, 2-oxindole -6-carboxylate. The second step was suspended in toluene at ambient temperature. Chloroacetic anhydride was added and the mixture was refluxed at 120 ° C for 3 hours, then cooled to 80 ° C and methylcyclohexane was added with 30 min and slowly cooled to ambient temperature, The mother liquor was separated and the solid was washed with ice-cold methanol and dried to give white crystals, which were the target compound Nintedanib intermediate 3, 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester CAS number 1160293-25-3.

Thera. Category:  Anti-cancer

Cas No.:  1160293-25-3

Synonym:Methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-2-oxo-, methyl ester;methyl 1-(chloroacetyl)-2-oxoindolin-6-ylcarboxylate;1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;


Molecular Weight: 309.32

Molecular formula:C18H15NO4

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html