Organic Compound 4-Methylcatechol CAS 452-86-8

Unit Price: USD 100.0000 - 148.0000 / Kilogram
Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 5 Days

Basic Info

Model No.: 452-86-8

Additional Info

Packaging: 25KGS/DRUM

Productivity: 1T/M


Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: UNLIMITED

Certificate: ISO

Product Description

4-methylcatechol CAS number is 452-86-8, It is a widely used organic compound, can be used for the preparation of pharmaceutical active compounds, It can also be used for the synthesis of antibacterial agents and antioxidants, and can be used as a high-impedance Polymerizers are used for the sterilization and anti-mildew of photosensitive materials and the production of apple-type perfumes. They are used in the daily life industry and have wide application prospects.

There has been extensive research on the synthesis of 4-methylcatechol cas 452-86-8. A one-step catalytic reaction using titanium-silicon molecular sieves and other catalysts has been reported. However, the highest yield is only 12% . Most of the raw materials need to be recycled, and the selectivity of the catalyst is low Or the yield is not high, and recycling is difficult. German experts use hydrogen peroxide for the hydroxylation of phenols in the presence of strong acids. The acid used is sulfuric acid or perchloric acid, which causes serious corrosion to the equipment, and the yield is less than 30%. Another article in Germany reported that sulfur dioxide or selenium dioxide is used as a catalyst to oxidize with almost anhydrous hydrogen peroxide. Although this method does not have strong acid corrosion,However, it is necessary to add an aldehyde compound or a complex component to intensify the process. The operation is cumbersome, and the almost anhydrous hydrogen peroxide solution has a large potential safety hazard. The selenium dioxide used is a highly toxic substance, which easily causes heavy metal pollution. In terms of biology, there are European and American patents that use catechol oxidase to catalyze the synthesis of 4-methylcatechol from p-cresol. Although the yield is high, the reaction conditions are harsh. It is not suitable for industrial production because of the maintenance of the activity of oxidase.

In view of the above-mentioned problems, p-cresol was used as a starting material to produce p-cresol acetate by acylation reaction and Fries rearrangement reaction in high-boiling inert solvent to obtain 2-hydroxy-5-methylacetophenone. Alkalinization into salt, low-temperature oxidation, the reaction is completed, the reaction solution by reduction, acidification, extraction and concentration of crude products, through distillation to obtain pure 4-methyl catechol. The advantage of this method is that the first two reaction products do not need to be purified, and the final product can be directly obtained by one-pot reaction. The operation is simple and the production cycle is short.

Thera. Category: Organic Raw material 

Cas No.:452-86-8

Synonym: 4-Methyl-1,2-dihydroxybenzene;4-methyl-2-benzenediol ;4-methyl-benzene-1,2-diol ;4-methyl-pyrocatecho ;p-methylcatechol ;p-Methylpyrocatechol;2-Hydroxy-4-methylphenol;4-Methyl-1,2-benzenediol (4-methylpyrocatechol);


Molecular Formula: C7H8O2

Molecular Weight: 124.14

Specifications: Available on request

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html