Universal Opioid Receptor Antagonist Nalmefene Hydrochloride CAS 58895-64-0

Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 58895-64-0

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Nalmefene hydrochloride cas number 58895-64-0,As a highly selective and specific endogenous opioid receptor antagonist, does not have the agonistic effect of opioids, but competes with the endogenous excess of endogenous opioid peptides. The method can bind to endogenous opioid receptors μ, κ, and δ, and the binding to mu receptor is the strongest. Nalmefene hydrochloride cas 58895-64-0 blocks a series of pathological reactions caused by central nervous system, respiratory and circulatory system caused by stress, and can inhibit or reverse the respiratory depression, sedation and hypotension of opioids; Or the treatment of synthetic anesthetic analgesic poisoning, also has some antagonism against some non-opioid poisoning, such as reversing the respiratory depression and coma caused by alcohol overdose.In 1995, nalmefene hydrochloride was listed in the United States. It is another new pure opioid receptor antagonist synthesized after naloxone and naltrexone. It is a derivative of water-soluble naltrexone, and its chemical structure of the 6-methylene group makes it exhibit physiologically stronger and more penetrating biofilm properties. Its plasma elimination half-life is 8.2-8.9h, compared with the similar compounds naloxone and naltrexone, its pharmacological action is long and the intensity of action is large. Poor side effects. Although there are slight headaches, burnout, blurred vision, etc. at higher doses, there is no obvious adverse reaction, so it is getting more and more attention from researchers. In 1995, approved by the US FDA, nalmefene hydrochloride was used to reverse the adverse reactions caused by opioids such as respiratory depression and blood pressure after surgery.
Currently, clinically, a formulation containing nalmefene hydrochloride is an oral preparation for oral administration and an injection for intravenous and intramuscular administration. Experiments show that nalmefene hydrochloride has the characteristics of long acting time, high bioavailability and few side effects. It has been used to antagonize respiratory depression caused by narcotic analgesics and for heart failure, shock, alcoholism, addiction, etc. treatment.

Thera. Category:Receptor antagonist

Cas No.:  58895-64-0


Synonym:Revex;Unii-K7K69qc05x;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride;(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol;17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride;nalmefene hydrochloride;NALMEFENE HCL;Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, (5alpha)-;

Molecular Formula:C21H25NO3.ClH

Molecular Weight:375.89


PackingExport worthy packing

lMaterial Safety Data SheetAvailable on request 

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