Venetoclax Intermediate or ABT-199 Intermediate CAS 1228837-05-5

Basic Info

Model No.: 1228837-05-5

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

CAS number 1228837-05-5 is one of the intermediate of ABT-199, Molecular formula:C15H17ClO, Molecular weight: 248.74788,We referred to this intermediate as ABT199 intermediate or Venetoclax Intermediate. At present this intermediate manufacturers are rarely, the output is not large, mostly suppliers stay in the laboratory scale level, only a few manufacturers enter into the pilot level of production scale. We simply introduce some synthetic routes used by some manufacturers.Use 3,3-dimethylcyclohexanone as a starting material, add POCl3, DMF  to obtain 2-chloro-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde (cas 1228943-80-3), then add 4-chlorophenylboronic acid to get the final product ABT 199 intermediate 1.
Thera. Category: Leukemia Drugs

Cas No.: 1228837-05-5

Synonyms: 2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carbaldehyde;2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enecarboxaldehyde;2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enecarbaldehyde;4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde;2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde;

Molecular Formula:C15H17ClO

Molecular Weight: 248.74788

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request