|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 112828-00-9
Function: Nervous System Drugs
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Calcipotriol CAS number is 112828-00-9, As known as Calcipotriene. It was successfully developed by the Danish pharmaceutical company in 1987 under the trade name Daivonex. It was listed in the UK, Denmark and Ireland in March 1991 and is licensed worldwide to Squibb, Fujisawa, and Schering Germany. As a representative of vitamin D3 analogues, Calcipotriol CAS number 112828-00-9 can inhibit excessive proliferation and induce differentiation of skin cells, thereby correcting the abnormality of proliferation and differentiation of psoriatic skin cells, and is excellent in the treatment of mild to moderate psoriasis. Efficacy. Its efficacy in treating psoriasis has also been shown in many clinical trials. Calcipotriol belongs to the class of non-corticosteroids and is an analogue of the vitamin D3 active metabolite 1,25-(OH)2-D3. The structure of calcipotriol is complex, with 7 chiral centers, three alcoholic hydroxyl groups, very soluble in 96% alcohol, but extremely insoluble in water, calcipotriol is sensitive to light and heat, easy to deteriorate, so the preparation difficulty great.
Studies have shown that calcipotriol is a strong regulator of keratinocyte differentiation and proliferation, reducing the level of epidermal IL-6 in activated psoriasis patients and the number of activated epidermal T lymphocytes, which can inhibit excessive proliferation and induction of keratinocytes. Its differentiation, so that the proliferation and differentiation of psoriatic lesions are corrected. Calcipotriol acts through the vitamin D receptor in the nucleus. Vitamin D3 receptors are present in cells involved in the pathogenesis of psoriasis such as keratinocytes, skin accessory cells, fibroblasts, monocytes, T lymphocytes, and activated B lymphocytes in the skin. Calcipotriol binds to the receptor, regulates biological changes in the cell, inhibits keratinocyte proliferation, enhances its morphology and biochemical differentiation, and causes cell growth and reproduction to proceed according to normal rules. At the same time, experimental studies have shown that calcipotriol can interact with and regulate the cell kinin pathway in skin inflammation and immune response.
Thera. Category:Psoriasis vulgaris
Molecular Formula: C27H44O3
Molecular Weight: 416.329
Packing: Export worthy packing
Material Safety Data Sheet: Available on request