2-Oxindole-6-carboxylic Acid Methyl Ester Used for Making Nintedanib 14192-26-8

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 14192-26-8

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Nintedanib intermediate,full chemical name is 2-Oxindole-6-carboxylic acid methyl ester CAS number 14192-26-8, in numerous patent reports,it is the starting material for the synthesis of nintedanib, the general process of synthesis of nintedanib As follows: Nintedanib was obtained by the steps of replacing, condensing, deprotecting and reducing of methyl 2-oxindole-6-carboxylate. However, these methods have obvious shortcomings. Some people have made improvements on the basis of these methods. However, both the patented method and the improved method of start materials are 2-Oxindole-6-carboxylic acid methyl ester,so it is the largest amount of an intermediate in the entire of Nintedanib reaction system. Due to the importance, we must pay attention to its manufacturing method. There is a very reasonable route, the general experimental process is as follows: 1. 200g 4-chloro-3-nitrobenzoic acid was suspended in methanol, 59g thionyl chloride was added within 15min, heated to reflux reaction at 70 ° C for 3 hours ,After cooling to 5 ° C, the product was isolated by centrifugation and dried at 45 ° C to get 189.2 g of the first step methyl 4-chloro-3-nitrobenzoate. 2. 107.3 g of sodium tert-pentoxide added into 128.7 g of dimethyl malonate and then added to 350 mL of hot solution(75 ° C) of N-methyl-2-pyrrolidone; 100 g of 4- Chloro-3-nitrobenzoate added into 250 mL of N-methyl-2-pyrrolidone. After stirring at about 75 ° C for 1.5 hours and cooling to 20 ° C, the mixture was acidified with 1000 mL of dilute hydrochloric acid to pH = 1 and 137.6 g of a solid was filtered off. The solid was dissolved in 880 mL of acetic acid and 10% palladium on carbon catalyst ,take hydrogenation reaction at 45 ° C, After the hydrogenation was stopped, the reaction material was heated to 115 ° C for 2 hours. The catalyst was filtered off and 1800 mL of water was added at about 50 ° C. The reaction product was re-cooled to 5 ° C and then centrifuged at Drying at 50 ° C to get 69.6 g of 2-Oxindole-6-carboxylic acid methyl ester CAS number 14192-26-8.

Thera. Category:  Anti-cancer

Cas No.:  14192-26-8

Synonym:Methyl2-oxoindoline-6-carboxylate97%;1H-Indole-6-carboxylicacid, 2,3-dihydro-2-oxo-, methyl ester;Menthyl 2-oxoindole-6-carboxylate;2-OXO-6-INDOLINECARBOXYLIC ACID METHYL ESTER


Molecular Weight: 191.19  

Molecular formula: C10H9NO3

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html