Direct Thrombin Inhibitor Dabigatran Etexilate Mesylate CAS 872728-81-9

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 872728-81-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA

Supply Ability: 60KG

Certificate: ISO

Product Description

Dabigatran Etexilate Mesylate CAS number is 872728-81-9,a new direct thrombin inhibitor, which has the characteristics of orally available, safe, less drug interactions, low risk of bleeding, suitable for a wide range of people, clinically Mainly for the prevention of stroke thrombosis and anti-thrombosis and other fields. Since the listing, The sales of dabigatran etexilate mesylate have increased exponentially year by year, and the market share has risen rapidly. Nowadays, dabigatran etexilate has become the third largest anticoagulant drug in the world after the two major heparins. Dabigatran etexilate mesylate significantly reduced the risk of stroke and systemic embolism by more than 35% and significantly reduced the risk of ischemic stroke by 24%, with a significant reduction in the risk of vascular death, intracranial hemorrhage, and fatal bleeding. The listing of dabigatran etexilate mesylateis a milestone in the area of anticoagulant therapy and potentially lethal thromboprophylaxis.
Dabigatran etexilate mesylate cas 872728-81-9 is a non-peptide direct thrombin inhibitor that through exerts anticoagulant effects by specifically and selectively blocking the activity of thrombin and is orally, potent and requires no special drug monitoring , Less drug interactions and so on. In 2008, dabigatran etexilate mesylate was approved in Europe and Canada for the prevention of acute venous thrombosis. US FDA approved the use of dabigatran etexilate mesylate to reduce stroke and systemic thrombosis in patients with nonvalvular atrial fibrillation in September 2010  .
Dabigatran etexilate mesylate is good soluble in various organic solvents, biggest solubility in methylene chloride but minimal solubility in water. Its apparent solubility decreased with increasing pH of the solution, reaching 13.49 mg / 1 mL in pH 1.0, about 1.89 mg / 1 mL at pH 2.0, 156 μg / mL at pH 3.0, 1mL, almost insoluble in pH> 5 buffer. Dabigatran etexilate mesylate has good solubility in the stomach at pH 1.0-3.0, but do not have enough permeability, and may have better permeability in the body fluid environment at pH 3.0-8.0 .

Thera. Category: Antithrombotic/Blood thinners

Cas No.:872728-81-9

Synonym:Dabigatran etexilate mesylate; Dabigatran etexilate Methanesulfonate


Molecular Weight:777.88628

Molecular formula: C27H29N7O3.C7H8O3S

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: It can treat and prevent blood clots, reducing the risk of stroke.

Related intermediate:

Chemical Name Specification Color
41263-74-5 4-(MethylaMino)-3-nitrobenzoic acid HPLC 99.0% pale brown
           103041-38-9 N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER HPLC 99.0% off white to white
           429659-01-8 ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE HPLC 99.0% orange yellow solid 
N-(4-CYANO-PHENYL)-GLYCINE HPLC 99.0%  off white  
Loss on drying 1.0%
Melting point 101.0°C~106.0°C
Single impurity 0.3% 
Loss on drying 0.5%
Residue on ignition 0.5% 
Assay 98.0%
Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester HPLC 99.0% off white  
Single impurity 0.3%
Loss on drying 0.5% 
Residue on ignition 0.5% 
Assay 99.0%
 872728-85-3 N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate HPLC 97.0% off white  
Dabigatran Etexilate HPLC 98.0%  white  
Single impurity 0.2%
Loss on drying 1.0% 
Assay 98.0%
Dabigatran etexilate mesylate HPLC 99.0%  light yellow solid
Single impurity 0.5%
Loss on drying 1.0% 
Residue on ignition 0.1% 
Heavy melta 20 ppm 
Assay 98.5%

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